Hydrogen Sulfide → 6-amino-1,5-dihydro-1-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)-4H-imidazo[4,5-c]pyridine-4-thione

Participants

Reaction Steps

A mixture of 8 g of 4-cyano-5-cyanomethyl-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazole, 250 ml of ethanol saturated at 0° C. with hydrogen sulfide, and 2.5 g of triethylamine is kept in a steel bomb for 48 hours at ambient temperature. The reaction solution is evaporated in vacuo to a yellow foam which is coevaporated with ethanol several times to provide 6-amino-1,5-dihydro-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-imidazo[4,5-c]pyridine-4-thione.

Provenance & Evidence