1H-1,2,4-Triazole → HCID 17993791, compound

HRID 1447014Notes

Reaction equation

HRID 1447014 reaction equation
Cl[CH2:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1>C(#N)C>[N:11]1([CH2:2][O:3][C:4]2[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=2)[CH:15]=[N:14][CH:13]=[N:12]1

Participants

4

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 88801alpha,4-Dichloroanisole

Product 1

HCID 17993791HCID 17993791, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

α-Chloro-p-chloroanisole (10.6 g) and 1,2,4-triazole (12.4 g) in acetonitrile (120 ml) were refluxed for 48 hours. After cooling to room temperature, triazole hydrochloride was filtered off and acetonitrile removed at reduced pressure to give a sticky gum which was extracted with hot petroleum ether (80°-100°) and allowed to cool slowly to give colourless prisms of the title compound.

Workup

  1. filtrationtriazole hydrochloride was filtered off
  2. customacetonitrile removed at reduced pressure
  3. customto give a sticky gum which
  4. extractionwas extracted with hot petroleum ether (80°-100°)
  5. temperatureto cool slowly

Sources & evidence

ORD record
ord-361a91f6e742462d9847d85fd681a006
Source dataset
uspto-grants-1982_02
Patent number
US04315016

Reaction notes

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