1H-1,2,4-Triazole → HCID 20495227, compound

HRID 1447015Notes

Reaction equation

HRID 1447015 reaction equation
Cl[CH:2]([O:4][CH2:5][CH:6]=[CH2:7])[CH3:3].[NH:8]1[CH:12]=[N:11][CH:10]=[N:9]1>C(#N)C>[N:8]1([CH:2]([O:4][CH2:5][CH:6]=[CH2:7])[CH3:3])[CH:12]=[N:11][CH:10]=[N:9]1

Participants

4

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 13099177HCID 13099177, compound

Product 1

HCID 20495227HCID 20495227, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Allyl 1-chloroethyl ether (3.6 g; Black and Lander, J.C.S., 1965, 5525) and 1,2,4-triazole (6.9 g) in acetonitrile (75 ml) were refluxed for 6 hours. The solvent was removed under reduced pressure; the residual solid was heated with water and extracted with diethyl ether. The ethereal phase was washed with water and dried over magnesium sulphate, and the solvent was removed. The residual oil was purified by passing through a column of silica gel, eluting with ethyl acetate to give the title compound as a colourless oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. temperaturethe residual solid was heated with water
  3. extractionextracted with diethyl ether
  4. washThe ethereal phase was washed with water
  5. dry with materialdried over magnesium sulphate
  6. customthe solvent was removed
  7. customThe residual oil was purified
  8. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-98fe6956dc1443f486e985b0a8c63b8d
Source dataset
uspto-grants-1982_02
Patent number
US04315016

Reaction notes

Loading…