反应详情

First 25.6 g (0.25 mol) of acetic anhydride and then 27.8 g (0.25 mol) of pivaloyl cyanide were introduced, in each case at room temperature, into 49.0 g (0.5 mol) of concentrated sulphuric acid, which had been initially introduced into the reaction vessel. After subsequently stirring the reaction mixture for 4 hours, 150 g of icewater were added and the mixture was stirred thoroughly. The reaction product which precipitated was filtered off, washed with 100 ml of water and dried. 37.0 g (86.5% of theory) of trimethylpyruvic acid N-acetylamide were obtained as colorless glistening flakes of melting point 82°-84° C.; content, according to determination by gas chromatography, >98%. No additional purification operations were required for further reactions.

1. additionhad been initially introduced into the reaction vessel
2. addition150 g of icewater were added
3. stirringthe mixture was stirred thoroughly
4. customThe reaction product which precipitated
5. filtrationwas filtered off
6. washwashed with 100 ml of water
7. customdried