Thionyl Chloride → HCID 88747391, compound

HRID 1447071Notes

Reaction equation

HRID 1447071 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([NH:10][C:11]2[CH:12]=[C:13]([C:17]3[NH:18][C:19](=[O:26])[C:20](=[CH:24][CH:25]=3)[C:21](O)=[O:22])[CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:2]=1.S(Cl)([Cl:29])=O>>[ClH:29].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([NH:10][C:11]2[CH:12]=[C:13]([C:17]3[NH:18][C:19](=[O:26])[C:20](=[CH:24][CH:25]=3)[C:21]([Cl:29])=[O:22])[CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:2]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 12832231HCID 12832231, compound

Product 1

HCID 88747391HCID 88747391, compound

Procedure

A mixture of 7.5 g (20 mmol) of the above pyridone acid and 25 ml of thionyl chloride is stirred overnight at room temperature. The solid is filtered, washed with ether and dried under high vacuum over phosphorus pentoxide to give 8.62 g of 6-[3-(3-pyridinylsulfonylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid chloride hydrochloride.

Workup

  1. filtrationThe solid is filtered
  2. washwashed with ether
  3. dry with materialdried under high vacuum over phosphorus pentoxide

Sources & evidence

ORD record
ord-148174eda73a408191f859833ad28019
Source dataset
uspto-grants-1982_02
Patent number
US04315014

Reaction notes

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