HCID 70545436, compound → Fluocortolone Pivalate EP Impurity C

Participants

Reaction Conditions

Reaction Steps

1.5 g of 9α-bromo-6α-fluoro-11β-hydroxy-16α-methyl-21-trimethylacetoxy-1,4-pregnadiene-3,20-dione is introduced at 220° C. into 20 ml of "Marlotherm" S and heated to boiling for 15 minutes under a vacuum of 19 mm Hg [bp19 =242° C⟧ After cooling, the mixture is diluted with methylene chloride and chromatographed on silica gel, thus obtaining 920 mg of 6α-fluoro-16α-methyl-21-trimethylacetoxy-1,4-pregnadiene-3,11,20-trione, mp 226°-227° C.

Provenance & Evidence