NIKKOMYCIN Z → HCID 178461725, compound

Participants

Reaction Steps

19 g of nikkomicin were dissolved in 75 ml of H2O, and 9 g of Alkylamine/CPG-1350 (Pierce Chem. Comp.) were added. After degassing the mixture in vacuo, it was left to stand at room temperature for 24 hours. The support material was filtered off, washed out with 800 ml of H2O and treated with 100 ml of 5% strength acetic acid at room temperature for 30 minutes. The filtrate was lyophilized. 116 mg of a residue, which was subsequently chromatographed on LiChroprep RP-8 using methanol/H2O (30:70), were obtained. Yield of X (after lyophilization): 18 mg.

Provenance & Evidence