Sodium Carbonate → HCID 70552636, compound

Participants

Reaction Steps

50 g of 1-(2-carboethoxy-4,5-dimethyl-pyrrol-3-oxy)-3-chloropropane, 35 g of 4-hydroxy-4-phenyl-piperidine and 50 g of sodium carbonate in 300 ml of N,N-dimethylformamide are heated for 20 hours at 100° C. When the mixture has cooled, it is partitioned between water and methylene chloride, the organic phase is evaporated under reduced pressure, the residue which remains in dissolved in a small amount of methanol, and a solution of hydrogen chloride in ether is added dropwise. The crystals which precipitate are filtered off, washed with ether and dried. 56 g of 3-[3-(4-phenyl-4-hydroxy-piperidino)-propoxy]-4,5-dimethylpyrrole-2-carboxylic acid ethyl ester hydrochloride, of melting point 165°-169° C., are obtained.

Provenance & Evidence