1,1'-Carbonyldiimidazole → HCID 178524752, compound

Participants

Reaction Steps

A mixture of 17.0 g (52 mmol) of the above pyrimidine acid, 16.85 g (104 mmol) of carbonyldiimidazole, and 170 ml tetrahydrofuran is stirred at 44°-50° for 35 min and at room temperature for 2 hrs. The solid is filtered, washed with tetrahydrofuran and ether, and dried overnight at 45° under reduced pressure to give 13.9 g of 2-[4-(trifluoroacetylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid imidazolide.

Provenance & Evidence