Dimethylformamide → HCID 178473129, compound

Participants

Reaction Steps

A mixture of 5.96 g (18 mmol) of the above pyrimidine acid, 4.37 g (27 mmol) of carbonyldiimidazole, and 90 ml of dimethylformamide is stirred at 60° for 10 min and at room temperature for 1.5 hrs. The reaction mixture is diluted with 100 ml of ether and the solid filtered, washed with ether, and dried to give 2.52 g of 2-[4-[(2-ethoxy-1,2-dioxoethyl)amino]phenyl]-4-hydroxy-5-pyrimidine carboxylic acid imidazolide. The filtrate is treated with 150 ml of ether and another 1.32 g of imidazolide is obtained.

Provenance & Evidence