Acetic Acid → HCID 13156307, compound

HRID 1447164Notes

Reaction equation

HRID 1447164 reaction equation
[CH:1]1[N:9]2[C:4]([NH:5][NH:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][N:2]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15].[C:21](O)(=[O:23])[CH3:22]>>[C:14]([N:5]1[C:4]2=[N:3][N:2]=[CH:1][N:9]2[C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[N:6]1[C:21](=[O:23])[CH3:22])(=[O:16])[CH3:15]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 135503117HCID 135503117, compound

Product 1

HCID 13156307HCID 13156307, compoundYield 91%

Procedure

7.0 g (0.04 mole) of 4,5-dihydro-s-triazolo[3,4-c]-benzo-as-triazine are added to a mixture of 35 ml of glacial acetic acid and 35 ml of acetic anhydride, and the reaction mixture is refluxed for 6 hours. At the end of the reaction the mixture is cooled, the product is precipitated with ether and filtered off. 9.4 g of the title compound are obtained; yield: 91%; m.p.: 186°-188° C.

Workup

  1. temperaturethe reaction mixture is refluxed for 6 hours
  2. customAt the end of the reaction the mixture
  3. temperatureis cooled
  4. customthe product is precipitated with ether
  5. filtrationfiltered off

Sources & evidence

ORD record
ord-4b2d8571d1bb4682bebda12ff5f579c5
Source dataset
uspto-grants-1982_02
Patent number
US04316022

Reaction notes

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