Propionyl chloride → HCID 13156310, compound

HRID 1447170Notes

Reaction equation

HRID 1447170 reaction equation
[CH:1]1[N:9]2[C:4]([NH:5][NH:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][N:2]=1.[C:14](Cl)(=[O:17])[CH2:15][CH3:16]>C1C=CC=CC=1>[C:14]([N:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]2[CH:1]=[N:2][N:3]=[C:4]2[NH:5]1)(=[O:17])[CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 62324Propionyl chlorideHCID 135503117HCID 135503117, compound

Product 1

HCID 13156310HCID 13156310, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 4.0 g (0.023 mole) of 4,5-dihydro-s-triazolo[3,4-c]benzo-as-triazine, 2.2 g (0.023 mole) of propionyl chloride and 50 ml of benzene is refluxed under nitrogen atmosphere. The reaction mixture is cooled and the separated product is filtered off. The title compound, melting at 244° C., is obtained with a yield of 70%. The product does not show melting point depression in admixture with the compound prepared according to Example 4.

Workup

  1. temperatureis refluxed under nitrogen atmosphere
  2. temperatureThe reaction mixture is cooled
  3. filtrationthe separated product is filtered off

Sources & evidence

ORD record
ord-4f609493e8bc4592b21efc1f2b527c9f
Source dataset
uspto-grants-1982_02
Patent number
US04316022

Reaction notes

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