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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1447185Generated: October 27, 2026

Pyridine → 1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride

https://huagongshe.com/reaction/1447185

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridineHCID 1049—
ReactantOxalyl chlorideHCID 65578—
ReactantSodium 1-(p-Methoxybenzyl)-1H-tetrazole-5-carboxylateHCID 23720170—
SolventBenzeneHCID 241—
Product1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chlorideHCID 20463870—

Reaction Conditions

Temperature15 °C

Reaction Steps

Following the procedure of Example 3, the sodium salt produced in Example 5 is stirred with pyridine in benzene at 6° C. with rapid addition of oxalyl chloride. The mixture is stirred at 15° C. for one half hour, stripped and scrubbed twice with benzene to yield 1-(p-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04316037
Source datasetuspto-grants-1982_02
ORD IDord-8e80e245788344c3a76928986be927fe
Source noteuspto-grants-1982_02