1-(4-Fluorophenyl)prop-2-yn-1-one(WXC08573) → HCID 13205870, compound

HRID 1447201Notes

Reaction equation

HRID 1447201 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([C:8]#[CH:9])=[O:7])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14](=[O:24])[N:15]([CH:21]([CH3:23])[CH3:22])[CH:16]=[CH:17][C:18]([CH3:20])=[CH2:19]>CCCCCC>[CH:21]([N:15]([CH:16]1[CH:17]=[C:18]([CH3:20])[CH2:19][CH:9]=[C:8]1[C:6]([C:5]1[CH:10]=[CH:11][C:2]([F:1])=[CH:3][CH:4]=1)=[O:7])[C:14]([O:13][CH3:12])=[O:24])([CH3:22])[CH3:23]

Participants

4

Reactant 2

HCID 125197831-(4-Fluorophenyl)prop-2-yn-1-one(WXC08573)HCID 53684414HCID 53684414, compound

Product 1

HCID 13205870HCID 13205870, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent2×

Procedure

To a stirred suspension of 67,9 g 4-fluorobenzoylacetylene in 160 ml hexane under reflux is added dropwise within 1 hour 78,8 g N-isopropyl-N-(3-methyl-1,3-butadienyl)-carbamic acid methylester in 40 ml hexane. After the addition is completed, the reaction mixture is stirred for additional 6 hours under reflux, and then cooled to room temperature, whereby the heading compound precipitates, m.p. 98°-102° C.

Workup

  1. temperatureunder reflux
  2. additionAfter the addition
  3. temperatureunder reflux
  4. customwhereby the heading compound precipitates

Sources & evidence

ORD record
ord-fd6d38a541404a399c561039894e734f
Source dataset
uspto-grants-1982_02
Patent number
US04316042

Reaction notes

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