Acetic Acid → 6-[4-(Acetylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid

HRID 1447285ノート

反応式

HRID 1447285 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:17])[C:11](=[CH:15][CH:16]=2)[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[C:18](O)(=[O:20])[CH3:19].C(OC(=O)C)(=O)C>CCOCC>[C:18]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][C:10](=[O:17])[C:11](=[CH:15][CH:16]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:7]=1)(=[O:20])[CH3:19]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 129189566-(4-Aminophenyl)-1,2-dihydro-2-oxonicotinic acid

生成物 1

HCID 128322736-[4-(Acetylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 11.5 g (50 mmol) of 6-(4-aminophenyl)-1,2-dihydro-2-oxonicotinic acid, 200 ml of acetic acid, and 10.5 ml (110 mmol) of acetic anhydride is heated at reflux for 4.5 hrs. The mixture is cooled and diluted with 150 ml of ether. The solid is filtered, washed with ether, and dried at 60° to give 13.6 g of 6-[4-(acetylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid; mp>260°.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 4.5 hrs
  3. temperatureThe mixture is cooled
  4. filtrationThe solid is filtered
  5. washwashed with ether
  6. customdried at 60°

出典と根拠

ORDレコード
ord-e8bc0296f03a444bb179ef8e87a97ce2
出典データセット
uspto-grants-1982_02
特許番号
US04315858

反応ノート

読み込み中…