HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 20551283, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-(4-Aminophenyl)-1,2-dihydro-2-oxonicotinic acid | HCID 12918956 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 20551283 | HCID 20551283 | 87.4% |
Reaction Steps
Using the method for the preparation of the side chain acid in Example 3, 4.62 g (20 mmol) of 6-(4-aminophenyl)-1,2-dihydro-2-oxonicotinic acid, 8.4 ml (60 mmol) of triethylamine, 8.0 ml (63 mmol) of chlorotrimethylsilane, 200 ml of dichloromethane, and 2.5 ml (30 mmol) of methyl chloroformate gives 5.04 g of 6-[4-(methoxycarbonylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04315858 |
| Source dataset | uspto-grants-1982_02 |
| ORD ID | ord-98800c8a54a94205ab6e950df5b3e49c |
| Source note | uspto-grants-1982_02 |