Ethyl isocyanate → HCID 20551275, compound

Participants

Reaction Steps

A suspension of 9.2 g (40 mmol) of 6-(4-aminophenyl)-1,2-dihydro-2-oxonicotinic acid, 100 ml of dimethylformamide, 4.8 ml (60 mmol) of ethyl isocyanate and 5.6 ml (40 mmol) of triethylamine is stirred at 25° for 16 hrs. The dimethylformamide is evaporated under reduced pressure and the residue is treated with 200 ml of water and the pH is adjusted to 2.0 with 1 N hydrochloric acid. The solid is filtered and washed with methanol, ether and dried to give 11.8 g of 6-[4-(N-ethylcarbamoylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid.

Provenance & Evidence