Acetic Anhydride → HCID 20551279, compound

HRID 1447293Notes

Reaction equation

HRID 1447293 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10](=[O:17])[C:11](=[CH:15][CH:16]=2)[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][CH:7]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C:18]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10](=[O:17])[C:11](=[CH:15][CH:16]=2)[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][CH:7]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 12832224HCID 12832224, compound

Product 1

HCID 20551279HCID 20551279, compound

Procedure

A mixture of 4.6 g (20 mmol) of 6-(3-aminophenyl)-1,2-dihydro-2-oxonicotinic acid and 100 ml of acetic anhydride is stirred at reflux for 2 hrs. The reaction is cooled and the solid filtered, washed with acetonitrile and ether, and dried to give 4.12 of 6-[3(acetylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid.

Workup

  1. temperatureat reflux for 2 hrs
  2. temperatureThe reaction is cooled
  3. filtrationthe solid filtered
  4. washwashed with acetonitrile and ether
  5. customdried

Sources & evidence

ORD record
ord-f097203c33704eab94451c9bf0e74508
Source dataset
uspto-grants-1982_02
Patent number
US04315858

Reaction notes

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