Thionyl Chloride → HCID 20551278, compound

Participants

Reaction Steps

A suspension of 3.81 g (14 mmol) of the above pyridone acid and 100 ml of thionyl chloride is stirred at 45° for 1 hr and at room temperature overnight. The reaction mixture is stirred for 3 hrs at 52°, cooled, and filtered. The solid is washed with hexane and dried under high vacuum over phosphorus pentoxide to give 3.57 g of 6-[3-(acetylamino)phenyl]-1,2-dihydro-2-oxonicotinoyl chloride.

Provenance & Evidence