Hydrochloric Acid → 6-(4-Aminophenyl)-1,2-dihydro-2-oxonicotinic acid

Participants

Reaction Steps

A suspension of 422 g (1.67 mol) of the above nitrile and 3650 ml of water containing 932 g of potassium hydroxide is heated at 105° for 40 hrs. The solution is cooled and acidified to pH 4.0 with 1360 ml of concentrated hydrochloric acid and 400 g of potassium hydroxide pellets are added with stirring. After filtration, the pH of the filtrate is adjusted to 4.5 with concentrated hyrochloric acid. The solid is filtered, suspended in 8 L of water and filtered. The solid is washed with mthanol and finally ethyl acetate and dried at 60° to give 328 g of the title compound; mp 314°-316° dec. ##STR21##

Provenance & Evidence