HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 6-Fluoro-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sarcosine | HCID 1088 | — |
| Reactant | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Fluoro-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione | HCID 22914547 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
7.2 g (0.04 mol) of 6-fluoroisatoic acid anhydride and 3.9 g (0.044 mol) of sarcosine are added to 10 ml of dimethyl sulphoxide and the mixture is heated at 100° C. for 30 minutes. After cooling and diluting with 15 ml of water, the separated substance is filtered off. After drying, there is obtained 6-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 214°-217° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04316839 |
| Source dataset | uspto-grants-1982_02 |
| ORD ID | ord-885f266f585340a582c7127835ada739 |
| Source note | uspto-grants-1982_02 |