反应详情

温度

20 °C

40 g (0.83 mol) of methylmercaptan were passed into 150 ml of methanol at -20° C. A solution of 45 g (0.83 mol) of sodium methylate in 200 ml of methanol was then added dropwise to the same temperature. 154 g (0.78 mol) of 1-bromo-3,3-dimethyl-4-fluoro-butan-2-one were now added dropwise at 0° C. The mixture was stirred for a further 12 hours at 20° C., the inorganic precipitate was filtered off and the filtrate was distilled. 99 g (77% of theory) of 3,3-dimethyl-4-fluoro-1-methylthio-butan-2-one of boiling point 86° C./10 mm Hg were obtained. ##STR30##

1. filtrationthe inorganic precipitate was filtered off
2. distillationthe filtrate was distilled