3-Methyl-2-butanone → HCID 86736716, compound

HRID 1447547Notes

Reaction equation

HRID 1447547 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:19]=1[OH:20])[CH2:8][C:9]1([CH3:16])[CH2:14]CC[CH2:11][C:10]1=[O:15])([CH3:4])([CH3:3])[CH3:2].CC(C(C)C)=O>>[C:21]([C:18]1[CH:17]=[C:7]([CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:19]=1[OH:20])[CH2:8][C:9]([C:10]([CH3:11])=[O:15])([CH3:14])[CH3:16])([CH3:22])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 112513-Methyl-2-butanoneHCID 20384141HCID 20384141, compound

Product 1

HCID 86736716HCID 86736716, compoundYield 65%

Procedure

If, in this example, the 2-methylcyclohexanone is replaced by an equivalent quantity of isopropyl methyl ketone, an otherwise identical procedure gives methyl [1-(3,5-ditert.-butyl-4-hydroxybenzyl)-isopropyl] ketone, melting point 75° C., in a yield of 65%.

Sources & evidence

ORD record
ord-00a8237c4bbc4ccba3f64c97dfd6869d
Source dataset
uspto-grants-1979_12
Patent number
US04177213

Reaction notes

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