2-Hexanone → HCID 20384146, compound

HRID 1447548Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:19]=1[OH:20])[CH2:8][C:9]1(C)[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15])([CH3:4])([CH3:3])[CH3:2].C(C(C)=O)CCC>>[C:21]([C:18]1[CH:17]=[C:7]([CH:6]=[C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])[C:19]=1[OH:20])[CH2:8][CH:9]([C:10]([CH3:11])=[O:15])[CH2:14][CH2:13][CH3:12])([CH3:22])([CH3:23])[CH3:24]

Participants

Reactant 2

HCID 115832-Hexanone

HCID 20384141HCID 20384141, compound

Product 1

HCID 20384146HCID 20384146, compoundYield 60%

Procedure

If, in this example, the 2-methylcyclohexanone is replaced by an equivalent quantity of methyl n-butyl ketone, an otherwise identical procedure gives methyl [1-(3,5-ditert.-butyl-4-hydroxybenzyl)-n-butyl] ketone, which boils at 120° C. at 0.01 mm Hg and is an oil, in a yield of 60%.

Sources & evidence

ORD record: ord-40650026d8194a2da9b2add1846bb27e
Source dataset: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04177213

Reaction notes

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