Acetophenone → HCID 44477659, compound

HRID 1447549Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:19]=1[OH:20])[CH2:8]C1(C)CCCCC1=O)([CH3:4])([CH3:3])[CH3:2].[C:25]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)(=[O:27])[CH3:26]>>[C:21]([C:18]1[CH:17]=[C:7]([CH2:8][CH2:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:27])[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:19]=1[OH:20])([CH3:24])([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 7410Acetophenone

HCID 20384141HCID 20384141, compound

Product 1

HCID 44477659HCID 44477659, compoundYield 53%

Procedure

If, in this example, the 2-methylcyclohexanone is replaced by an equivalent quantity of acetophenone, an otherwise identical procedure gives phenyl (3,5-ditert.butyl-4-hydroxyphenylethyl) ketone in a yield of 53%.

Sources & evidence

ORD record: ord-89982ee4c0484e05ad87dcb364b1e139
Source dataset: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04177213

Reaction notes

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