Hydrazine hydrate (1:1) → 2-Aminomethyl-6-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

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Reaction Steps

14 g of 2-phthalimidomethyl-6-methyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester are heated to the boil in 150 ccs of ethanol, with the addition of 5 ccs of hydrazine hydrate, for 2-3 hours, the mixture is filtered hot and the filtrate is filtered again after cooling and concentrated in vacuo.

Provenance & Evidence