Pyridine → HCID 12608574, compound

HRID 1447597Notes

Reaction equation

HRID 1447597 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([NH:18][C:19]([NH2:21])=[O:20])[CH2:14][CH2:13]2)=[CH:2]1.N1C=CC=CC=1.[CH:28]1([C:34](Cl)=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>C1C=CC=CC=1>[CH:28]1([C:34]([NH:21][C:19]([NH:18][CH:15]2[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][C:3]3[C:4]4[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=4)[NH:1][CH:2]=3)[CH2:17][CH2:16]2)=[O:20])=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 75938Cyclohexanecarbonyl chlorideHCID 12608470N-{1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl}urea

Product 1

HCID 12608574HCID 12608574, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a suspension of 1-[1-(2-[3-indolyl]ethyl)piperid-4-yl]urea (0.35 g) in dry benzene (2 ml) was added anhydrous pyridine (0.12 g) and then cyclohexanoyl chloride (0.18 g). After refluxing the mixture for 2 hours, the title compound was filtered off, washed, dried and converted in ethanolic hydrogen chloride to the hydrochloride (0.52 g) m.p. 236.3° C.

Workup

  1. temperatureAfter refluxing the mixture for 2 hours
  2. filtrationthe title compound was filtered off
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-a86696559485434db4d30371e71841cf
Source dataset
uspto-grants-1979_12
Patent number
US04177279

Reaction notes

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