Sodium Hydroxide → 6-(Phenylsulfanyl)imidazo[1,2-a]pyridin-2-amine

HRID 1447599Notes

Reaction equation

HRID 1447599 reaction equation
[C:1]1([S:7][C:8]2[CH:9]=[CH:10][C:11]3[N:12]([CH:14]=[C:15]([NH:17]C(=O)C(F)(F)F)[N:16]=3)[CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[NH2:17][C:15]1[N:16]=[C:11]2[CH:10]=[CH:9][C:8]([S:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:13][N:12]2[CH:14]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54018566HCID 54018566, compound

Product 1

HCID 124108496-(Phenylsulfanyl)imidazo[1,2-a]pyridin-2-amine

Procedure

A suspension of 0.200 g. of 6-(phenylthio) 2-(trifluoroacetamido) imidazo [1,2-a] pyridine in 1 ml. of 2.5 N aqueous sodium hydroxide is stirred for 90 minutes at room temperature. The reaction mixture is extracted with methylene chloride and the extracts are washed with water and dried over magnesium sulfate. Evaporation of the solvent yields 2-amino 6-(phenylthio) imidazo [1,2-a] pyridine, m.p. 110°-112° C.

Workup

  1. additionA suspension of 0.200 g
  2. extractionThe reaction mixture is extracted with methylene chloride
  3. washthe extracts are washed with water
  4. dry with materialdried over magnesium sulfate
  5. customEvaporation of the solvent

Sources & evidence

ORD record
ord-9162dde19cc64a0782ef2d3d8734d8d5
Source dataset
uspto-grants-1979_12
Patent number
US04177274

Reaction notes

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