反应详情

A stirred solution of 7-amino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one (0.36 g, 1.15 mmol) in chloroform (10 ml) is treated at room temperature with N-bromosuccinimide (0.21 g, 1.2 mmol, 1.05 eq.). After stirring for 20 min, the mixture is partitioned between water (150 ml) and ethyl acetate (50 ml). The organic phase is washed with brine (100 ml), dried (magnesium sulfate) and filtered, and the solvent is removed by evaporation in vacuo to afford the title compound as an orange solid. The product is used in the next step without further purification.

1. customthe mixture is partitioned between water (150 ml) and ethyl acetate (50 ml)
2. washThe organic phase is washed with brine (100 ml)
3. dry with materialdried (magnesium sulfate)
4. filtrationfiltered
5. customthe solvent is removed by evaporation in vacuo