Potassium Hydroxide → HCID 54394348, compound

HRID 1447603Notes

Reaction equation

HRID 1447603 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([O:21]C(=O)C)=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:25]=1)=[O:4].[OH-].[K+]>CO.O>[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:25]=1)=[O:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 53698142HCID 53698142, compound

Product 1

HCID 54394348HCID 54394348, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

1.0 Gm. of the acetate derivative obtained in Example 15 is heated with a 10 ml. 50% methanol-water solution of 0.5 g. of potassium hydroxide for one hour. After evaporation of the methanol in vacuo the reaction mixture is acidified with glacial acetic acid. The resultant solids are removed by filtration, washed with water and dried to yield 2-(methoxycarbonylamino) 6-(p-hydroxyphenylthio) imidazo [1,2-a] pyridine.

Workup

  1. customAfter evaporation of the methanol in vacuo the reaction mixture
  2. customThe resultant solids are removed by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-210d659c43c74d5ca02ae2bd7e02eeff
Source dataset
uspto-grants-1979_12
Patent number
US04177274

Reaction notes

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