2-[(Acetylsulfanyl)methyl]-5-aminopentanoic acid → 5-Amino-2-mercaptomethylpentanoic acid

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Reaction Steps

2-Acetylthiomethyl-5-aminopentanoic acid (1 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under a blanket of argon. The solution is stored for twenty minutes at room temperature and concentrated to dryness in vacuo. The residue is applied to a column of Dowex 50 in the hydrogen cycle, the column is washed with water and 5-amino-2-mercaptomethylpentanoic acid is eluted with 2 M pyridine-acetate buffer pH 6.5.

Provenance & Evidence