Thionyl Chloride → Benzhydrylthioacetyl chloride

HRID 1447644Notes

Reaction equation

HRID 1447644 reaction equation
[CH:1]([CH2:14][C:15](O)=[S:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>C1C=CC=CC=1>[CH:1]([CH2:14][C:15]([Cl:20])=[S:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178526172HCID 178526172, compound

Product 1

HCID 18769441Benzhydrylthioacetyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

19.5 g (0.076 mol) of benzhydrylthioacetic acid in 114 ml of benzene are placed in a three-necked flask provided with a condenser and a dropping funnel. The mixture is heated and 19 ml of thionyl chloride are added drop by drop. Once the addition is complete, the reflux is continued for about 1 hour, cooling and filtering are carried out and the benzene and the excess thionyl chloride and then evaporated. In this way, a clear orange oil is obtained.

Workup

  1. customprovided with a condenser and a dropping funnel
  2. temperatureThe mixture is heated
  3. additionOnce the addition
  4. temperaturecooling
  5. filtrationfiltering
  6. customthe benzene and the excess thionyl chloride and then evaporated
  7. customIn this way, a clear orange oil is obtained

Sources & evidence

ORD record
ord-2abe3ad6ca93492494aa196319ebb94c
Source dataset
uspto-grants-1979_12
Patent number
US04177290

Reaction notes

Loading…