反应详情

35 ml of ammonia in 40 ml of water are introduced into a three-necked flask provided with a condenser and a dropping funnel and the benzhydrylthioacetyl chloride dissolved in about 100 ml of methylene chloride is added drop by drop. Once the addition is complete, the organic phase is washed with a dilute solution of soda and dried over Na2SO4, the solvent is evaporated and the residue is taken up in diisopropyl ether; in this way, the benzhydrylthioacetamide is crystallised. 16.8 g of product (yield=86%) are obtained.

1. customprovided with a condenser and a dropping funnel
2. additionis added drop by drop
3. additionOnce the addition
4. washthe organic phase is washed with a dilute solution of soda
5. dry with materialdried over Na2SO4
6. customthe solvent is evaporated
7. customin this way, the benzhydrylthioacetamide is crystallised