反应详情

A mixture of methyl 3-(2-chloroacetamido)-benzoate (16 g., 0.07 mole) and potassium thiolacetate (7.1 g., 0.065 mole) in 150 ml. of acetone is refluxed for 4.5 hr. After cooling, the reaction mixture is filtered and the filtrate concentrated under reduced pressure. The residual solid thus obtained is slurried with n-hexane to afford an 86% yield of crude product. Crystallization of the crude product from ethyl acetate-n-hexane affords analytically pure METHYL 3-[2-(ACETYLTHIO)ACETAMIDO]BENZOATE, m.p. 117.5°-119.5° C.

1. temperatureAfter cooling
2. filtrationthe reaction mixture is filtered
3. concentrationthe filtrate concentrated under reduced pressure
4. customThe residual solid thus obtained
5. customto afford an 86% yield of crude product
6. customCrystallization of the crude product from ethyl acetate-n-hexane