反应详情

A mixture of tetrahydro-3,5-bis-(phenylmethylene)-4H-thiopyran-4-one (5.84 g, 20 mmole) and n-propyl hydrazine (1.48 g, 20 mmole, CA 59:8724f) in MeOH (100 ml) is heated at reflux temperature for 3 hours. The initial heterogeneous mixture becomes homogeneous after about 0.5 hour. Upon cooling, crystals form and are collected and washed (MeOH) to give 5.0 g, m.p. 106°-118°. Recrystallization from MeOH gives the major product.

1. temperatureis heated
2. temperatureat reflux temperature for 3 hours
3. temperatureUpon cooling
4. customcrystals form and are collected
5. washwashed (MeOH)
6. customto give 5.0 g, m.p. 106°-118°
7. customRecrystallization from MeOH
8. customgives the major product