Phenethyl bromide → HCID 20293505, compound

HRID 1447808Notes

Reaction equation

HRID 1447808 reaction equation
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[CH:4]([C:6]1([OH:12])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:5].[CH2:15](Br)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)C>[OH:12][C:6]1([CH:4]([CH3:5])[C:3]([N:2]([CH3:1])[CH3:14])=[O:13])[CH2:7][CH2:8][N:9]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 20383018HCID 20383018, compound

Product 1

HCID 20293505HCID 20293505, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-hydroxy-4-piperidyl)propionic acid N,N-dimethylamide and phenethyl bromide are reacted in a manner analogous to that described in Example 3. The resulting crude title compound is dissolved in ethanol, the calculated amount of furmaric acid is added and subsequently ether is added until the solution becomes turbid. The resulting hydrogen fumarate form of the title compound has a M.P. of 188°-189° after recrystallization from ethanol/ether.

Sources & evidence

ORD record
ord-a622f6a73278411083cdbf01253aff67
Source dataset
uspto-grants-1979_12
Patent number
US04178377

Reaction notes

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