Ammonium Chloride → HCID 20293151, compound

HRID 1447833Notes

Reaction equation

HRID 1447833 reaction equation
[CH2:1]([O:8][C:9]1[C:18]2[O:17][CH2:16][CH2:15][O:14][C:13]=2[C:12]([NH:19][C:20]([O:22]CC)=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+:26]>N1CCOCC1>[CH2:1]([O:8][C:9]1[C:18]2[O:17][CH2:16][CH2:15][O:14][C:13]=2[C:12]([NH:19][C:20]([N:26]2[CH2:10][CH2:9][O:8][CH2:1][CH2:2]2)=[O:22])=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 20293156HCID 20293156, compound

Product 1

HCID 20293151HCID 20293151, compound

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Procedure

A mixture of 38 g of 5-benzyloxy-8-ethoxycarbonylamino-1,4-benzodioxane (XIg), code number 770 522, and 300 ml of morpholine was brought to reflux for 16 hours, in the presence of a pinch of ammonium chloride. Then the morpholine in excess was evaporated and the residue was recrystallized in 96° ethanol.

Workup

  1. customThen the morpholine in excess was evaporated
  2. customthe residue was recrystallized in 96° ethanol

Sources & evidence

ORD record
ord-1e67926b06c64088b238af39221fcf4b
Source dataset
uspto-grants-1979_12
Patent number
US04178442

Reaction notes

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