3'-(Trifluoromethyl)acetophenone → 3-Dimethylamino-3'-trifluoromethylacrylophenone

Participants

Reaction Steps

A reaction mixture of 50 g. of m-trifluoromethylacetophenone and 50 ml. of dimethylformamide dimethylacetal is refluxed for 16 hours under anhydrous conditions and then evaporated in vacuo to a thick orange-red oil. Hexane is added, the mixture is chilled and the desired product is collected by filtration as yellow crystals, m.p. 60.5°-62° C.

Provenance & Evidence