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Ethanol → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate | HCID 70477828 | — |
| 反応物 | HCID 178510443 | HCID 178510443 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 2741014 | — |
反応手順
A solution of 0.54 g. of 3-aminopyrazole-4-carbonitrile and 1.29 g. of 3-hydroxy-3'-(trifluoromethyl)acrylophenone acetate in 25 ml. of absolute ethanol is refluxed for 15 hours. The mixture is cooled and filtered giving a solid which is dissolved in methylene chloride and treated as described in Example 1, giving the desired product, m.p. 141°-142.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04178449 |
| 出典データセット | uspto-grants-1979_12 |
| ORD ID | ord-a736a5ca521844769a26308750dad5c6 |
| 出典メモ | uspto-grants-1979_12 |