HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Reactant | HCID 178469928 | HCID 178469928 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester | HCID 11198437 | — |
Reaction Steps
A mixture of 5.0 g. of 3-amino-4-carbethoxypyrazole and 7.84 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone in 25 ml. of glacial acetic acid is refluxed for 6 hours and then evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 97°-99° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04178449 |
| Source dataset | uspto-grants-1979_12 |
| ORD ID | ord-13d05cd1c0d54fd48fc7d100aa4797cf |
| Source note | uspto-grants-1979_12 |