HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → 3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 2'-(Trifluoromethyl)acetophenone | HCID 87095 | — |
| Product | 3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one | HCID 54259832 | — |
Reaction Steps
A mixture of 35 g. of o-trifluoromethylacetophenone in 35 ml. of dimethylformamide dimethylacetal is refluxed for 8 hours under anhydrous conditions and then evaporated to a yellow oil. Bulb to bulb distillation gives the desired product as a thick yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04178449 |
| Source dataset | uspto-grants-1979_12 |
| ORD ID | ord-b31ea636f6bc4460bfddb9389ddaf273 |
| Source note | uspto-grants-1979_12 |