3-Dimethylamino-3'-trifluoromethylacrylophenone → HCID 23329830, compound

HRID 1447879Notes

Reaction equation

HRID 1447879 reaction equation
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.NC1[N:20]=[CH:21][NH:22][C:23]=1[Cl:24]>C(O)(=O)C>[F:16][C:13]([F:14])([F:15])[C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[N:20]3[CH:21]=[N:22][C:23]([Cl:24])=[C:17]3[N:2]=[CH:3][CH:4]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 23329852HCID 23329852, compound

Product 1

HCID 23329830HCID 23329830, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 40 ml. of glacial acetic acid and 0.01 mole of 4-amino-5-chloroimidazole is refluxed for 6 hours. The solvent is removed under reduced pressure and the residue worked up as for Example 29 to give the product of the example.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customto give the product of the example

Sources & evidence

ORD record
ord-8345c3af46784c2085f7a47851ed8e8b
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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