Acetic Acid → HCID 23329856, compound

HRID 1447880Notes

Reaction equation

HRID 1447880 reaction equation
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[N:20]=[CH:21][NH:22][C:23]=1C#N.[C:26](O)(=O)C>>[CH3:26][C:3]1[CH:4]=[C:5]([C:7]2[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=2)[N:20]2[CH:21]=[N:22][C:23]([C:19]#[N:18])=[C:17]2[N:2]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 787775-amino-1H-imidazole-4-carbonitrileHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

Product 1

HCID 23329856HCID 23329856, compound

Procedure

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 0.01 mole of 4-amino-5-imidazolecarbonitrile is refluxed for 5 hours. The solvent is removed under reduced pressure and the residue worked up as for Example 29 to give the product of the example.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customto give the product of the example

Sources & evidence

ORD record
ord-cd76b40de25b451294820b24e35cf563
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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