HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-amino-1H-imidazole-4-carbonitrile → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-amino-1H-imidazole-4-carbonitrile | HCID 78777 | — |
| Reactant | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile | HCID 15712556 | — |
Reaction Steps
A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 0.01 mole of 4-amino-5-imidazolecarbonitrile in 30 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed under reduced pressure and worked up as for Example 29 to give the product as crystals, m.p. 168°-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04178449 |
| Source dataset | uspto-grants-1979_12 |
| ORD ID | ord-898ae87d03134808bfed142c16a1fd9e |
| Source note | uspto-grants-1979_12 |