5-Aminoimidazole-4-carboxamide hydrochloride → 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Participants

Reaction Steps

A mixture of 1.62 g. of 4-amino-5-imidazolecarboxamide hydrochloride, 3-dimethylamino-3'-methoxyacrylophenone, 0.82 g. of sodium acetate and 25 ml. of glacial acetic acid is refluxed for 10 hours. The mixture is evaporated to dryness and the residue worked up to give 4-(m-methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide. This compound is treated as for Example 29 with trifluoroacetic anhydride to give the product of the example.

Provenance & Evidence