Acetic Acid → HCID 23329871, compound

HRID 1447889Notes

Reaction equation

HRID 1447889 reaction equation
[CH3:1][CH:2]([C:4]1[CH:5]=[N:6][N:7]2[C:12]([C:13]3[CH:14]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:17][CH:18]=3)=[CH:11][CH:10]=[N:9][C:8]=12)[OH:3].C(O)(=O)C>[O-2].[O-2].[O-2].[Cr+6].O>[F:21][C:19]([F:20])([F:22])[C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:12]2[N:7]3[N:6]=[CH:5][C:4]([C:2]([CH3:1])=[O:3])=[C:8]3[N:9]=[CH:10][CH:11]=2)[CH:14]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 23329841HCID 23329841, compound

Product 1

HCID 23329871HCID 23329871, compound

Reagents, catalysts & solvents 2

HCID 10219390chromium (VI) trioxideCatalystHCID 962WaterSolvent

Procedure

A mixture of 3.0 g. of α-methyl-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-methanol and one gram of chromium trioxide in 75 ml. glacial acetic acid is allowed to remain at room temperature for 1 hour and then poured into water. The resultant solid is removed by filtration and then recrystallized from methylene chloride-n-hexane to yield the desired methyl ketone, m.p. 127°-130° C.

Workup

  1. additionA mixture of 3.0 g
  2. customThe resultant solid is removed by filtration
  3. customrecrystallized from methylene chloride-n-hexane
  4. customto yield the desired methyl ketone, m.p. 127°-130° C.

Sources & evidence

ORD record
ord-fedc62ac039244c2aac7ea04fb4ac17c
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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