Sodium Acetate → HCID 11206368, compound

HRID 1447899Notes

Reaction equation

HRID 1447899 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]2[N:14]=[CH:15][CH:16]=[C:4]2[N:3]=1.C([O-])(=O)C.[Na+]>[Pd]>[C:8]1([C:6]2[CH:7]=[CH:2][N:3]3[N:14]=[CH:15][CH:16]=[C:4]3[N:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 2332986033149-19-8

Product 1

HCID 11206368HCID 11206368, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2.29 g. of 5-chloro-7-phenylpyrazolo-[1,5-a]pyrimidine, 0.90 g. anhydrous sodium acetate, and 0.30 g. of 10% palladium on charcoal catalyst in 100 ml. of absolute alcohol is hydrogenated at 10 lbs. pressure. Uptake stops in 45 minutes and catalyst is filtered. Evaporation and solution in methylene chloride with passage through a short hydrous magnesium silicate column gives the solution from which the desired compound crystallizes upon the addition of hexane, m.p. 122°-124° C.

Workup

  1. additionA mixture of 2.29 g
  2. filtrationcatalyst is filtered
  3. customEvaporation and solution in methylene chloride with passage through a short hydrous magnesium silicate column

Sources & evidence

ORD record
ord-8554cabfb0da498e9a2b4f137fd57141
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Reaction notes

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