反应详情

A solution of α-isopropyl-4-trifluoromethoxyphenylacetyl chloride (4.58 mmole) in ether (5 ml) is added to a ether (20 ml) solution of α-cyano-m-phenoxybenzyl alcohol (4.58 mmole) and pyridine (0.5 ml). The mixture is stirred overnight and filtered. The filtrate and the washings are evaporated and the residual oil is purified on 5×2 mm silica gel plates using 1:1 methylenechloride-hexane as eluent. The band with Rf=0.55 is extracted with ether and evaporated to give the desired ester (0.85 g).

1. filtrationfiltered
2. customThe filtrate and the washings are evaporated
3. customthe residual oil is purified on 5×2 mm silica gel plates
4. extractionThe band with Rf=0.55 is extracted with ether
5. customevaporated