反应详情

α-Isopropyl-4-trifluoromethylthiophenylacetonitrile (6.9 g real, 0.0265 mol) and 50% sodium hydroxide (25 g, 0.312 mol) are combined in 53 ml of ethylene glycol and heated at gentle reflux for 18 hours. The reaction is poured into ice water and extracted with ether. The aqueous phase is acidified with concentrated HCl, then re-extracted with ether which is washed with water and dried over sodium sulfate. Evaporation in vacuo gives 2.05 g of an oil product.

1. temperatureheated
2. temperatureat gentle reflux for 18 hours
3. extractionextracted with ether
4. extractionre-extracted with ether which
5. washis washed with water
6. dry with materialdried over sodium sulfate
7. customEvaporation in vacuo