反应详情

A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.

1. temperatureis heated at 60°-65° C. for 18 hours
2. temperatureThe mixture is cooled
3. extractionextracted in its ether
4. washwashed with water, saturated sodium chloride solution
5. dry with materialdried (CNa2SO4)
6. customEvaporation of the solvent
7. customgives a solid, (33.2 g)